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Share-Based Payments (Tables)
 9 Months Ended
Sep. 30, 2019
Share-based Payment Arrangement [Abstract]  
Schedule of Company's Stock Option Activity
The following table presents stock option activity for the nine months ended September 30, 2019:
Number of
Stock Options
Weighted-Average
Exercise Price
Outstanding at December 31, 20185,416,069  $60.10  
Granted1,577,686  55.85  
Exercised(253,323) 34.51  
Forfeited/Expired(554,497) 67.59  
Outstanding at September 30, 20196,185,935  $59.39  
Exercisable at September 30, 20193,441,309  $58.90  
Vested and expected to vest at September 30, 20196,185,935  $59.39  
Unvested Stock Unit Activity
The following table presents restricted stock unit, or RSU, activity for the nine months ended September 30, 2019:
Number of
Stock Units
Weighted-Average
Grant Date Fair 
Value
Unvested shares at December 31, 2018532,144  $75.45  
Granted437,227  57.25  
Vested(160,703) 69.52  
Forfeited(75,568) 71.79  
Unvested shares at September 30, 2019733,100  $66.28  
Schedule of Performance-Based Units
The following table presents performance-based stock unit, or PSU, activity for the nine months ended September 30, 2019:
Number of
Stock Units
Weighted-Average
Grant Date Fair 
Value
Unvested shares at December 31, 2018169,031  $52.67  
Granted180,761  58.64  
Vested(167,031) 52.36  
Unvested shares at September 30, 2019182,761  $58.87  
Schedule of Market-Based Units Activity
The following table presents market-based stock unit, or MSU, activity for the nine months ended September 30, 2019:
Number of
Stock Units		Weighted-Average
Grant Date Fair
Value
Unvested shares at December 31, 2018—  $—  
Granted42,695  41.50  
Unvested shares at September 30, 201942,695  $41.50  
Schedule of Stock-Based Compensation Expense by Award Type Included Within the Condensed Consolidated Statements of Operations
Stock-based compensation expense by award type included within the condensed consolidated statements of operations is as follows (in thousands):
Three Months Ended
September 30,		Nine Months Ended
September 30,
2019201820192018
Stock options$11,552  $12,953  $37,065  $38,736  
Restricted stock units4,917  3,338  14,708  7,940  
Employee stock purchase plan350  246  1,070  838  
Other stock awards1,769  7,656  2,400  7,656  
Total stock-based compensation expense$18,588  $24,193  $55,243  $55,170  
Schedule of Allocated Stock-Based Compensation Expense
Expenses related to stock options and stock-based awards were allocated as follows in the condensed consolidated statements of operations (in thousands):
Three Months Ended
September 30,		Nine Months Ended
September 30,
2019201820192018
Research and development expense$9,860  $13,399  $29,969  $31,706  
Selling, general and administrative expense8,728  10,794  25,274  23,464  
Total stock-based compensation expense$18,588  $24,193  $55,243  $55,170