X0306 4 2018-02-16 0 0001439222 AGIOS PHARMACEUTICALS INC AGIO 0001578200 Schenkein David P C/O AGIOS PHARMACEUTICALS, INC. 88 SIDNEY STREET CAMBRIDGE MA 02139 1 1 0 0 Chief Executive Officer Stock option (right to buy) 77.70 2018-02-16 4 A 0 97500 0.00 A 2028-02-15 Common stock 97500 97500 D Restricted stock units 2018-02-16 4 A 0 24375 0.00 A Common stock 24375 24375 D This option was granted on February 16, 2018. The shares underlying this option vest as to 25% of the underlying shares on February 16, 2019, with the remaining 75% vesting in 36 equal monthly installments thereafter. Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. The restricted stock units were granted on February 16, 2018. The shares underlying the restricted stock units will vest in three equal annual installments on February 16, 2019, 2020 and 2021. Vested shares will be delivered to the reporting person within three business days after such shares become vested. /s/ William Cook, as Attorney-in-fact for David Schenkein 2018-02-20