X0306 4 2015-01-28 0 0001439222 AGIOS PHARMACEUTICALS INC AGIO 0001581950 Cantley Lewis Clayton Jr. C/O AGIOS PHARMACEUTICALS, INC. 88 SIDNEY STREET CAMBRIDGE MA 02139 1 0 0 0 Common stock 2016-01-28 4 S 0 627 44.33 D 132340 D Common stock 2016-01-28 4 S 0 625 44.33 D 132340 I See footnote Common stock 2016-01-29 4 S 0 627 41.52 D 131713 D Common stock 2016-01-29 4 S 0 625 41.52 D 131715 I See footnote This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $43.55 to $45.73. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. Shares held by Vicki Lee Sato, who is the reporting person's spouse. The price reported is the weighted average of the shares sold. The shares were sold at varying prices in the range of $40.66 to $43.03. The reporting person undertakes, upon request by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price. /s/ Glenn Goddard, as Attorney-in-Fact for Lewis C. Cantley Jr. 2016-02-01