X0306 4 2016-01-04 0 0001439222 AGIOS PHARMACEUTICALS INC AGIO 0001581954 Higgons John Duncan C/O AGIOS PHARMACEUTICALS, INC. 88 SIDNEY STREET CAMBRIDGE MA 02139 0 1 0 0 Chief Operating Officer Common stock 2016-01-04 4 M 0 57024 2.34 A 118859 D Common stock 2016-01-04 4 M 0 1975 31.64 A 120834 D Stock option (right to buy) 2.34 2016-01-04 4 M 0 57024 0.00 D 2022-04-05 Common stock 57024 182088 D Stock option (right to buy) 31.64 2016-01-04 4 M 0 1975 0.00 D 2024-03-04 Common stock 1975 180113 D This option was granted on April 6, 2012 for the purchase of 63,636 shares of common stock. The option vests as to 25% upon the achievement of a performance milestone, as to an additional 50% upon the achievement of a second performance milestone, and as to the remaining 25% on the first anniversary of the first date that both performance milestones were achieved. The performance criteria for the first performance milestone were met on March 18, 2013. The performance criteria for the second performance milestone were met on April 4, 2014, and the remaining shares vested on April 4, 2015. This option was granted on March 5, 2014. The shares underlying this option vest as to 25% of the underlying shares on March 5, 2015, with the remaining 75% vesting in 36 equal monthly installments thereafter. /s/ Glenn Goddard, as Attorney-in-Fact for John Duncan Higgons 2016-01-05