X0101 EFFECT 33 LIVE 2015-04-23 12:00:00

F-4

0001438569 Grifols SA 333-203164 0001637839 Grifols Worldwide Operations Ltd 333-203164-08 0001532266 Biomat USA Inc. 333-203164-07 0001532265 Grifols Biologicals Inc. 333-203164-06 0001637912 Grifols Diagnostic Solutions Inc. 333-203164-05 0001532264 Grifols Shared Services North America Inc. 333-203164-04 0001486778 Grifols Therapeutics, Inc. 333-203164-03 0001638017 Grifols Worldwide Operations USA, Inc. 333-203164-02 0001637949 Instituto Grifols, S.A. 333-203164-01