CONSOLIDATED STATEMENT OF CHANGES IN STOCKHOLDERS' DEFICIT - USD ($) $ in Thousands	Total	Employees	Non-employees	Private Placement, January 2013	Private Placement, February 2013	Private Placement, August 2013	February Investors	Public Offering, January 2014	Public Offering, March 2015	Common Stock	Common Stock Employees	Common Stock Non-employees	Common Stock Private Placement, January 2013	Common Stock Private Placement, February 2013	Common Stock Private Placement, August 2013	Common Stock February Investors	Common Stock Public Offering, January 2014	Common Stock Public Offering, March 2015	Common Stock in Treasury	Additional paid in capital	Additional paid in capital Employees	Additional paid in capital Non-employees	Additional paid in capital Private Placement, January 2013	Additional paid in capital Private Placement, February 2013	Additional paid in capital Private Placement, August 2013	Additional paid in capital February Investors	Additional paid in capital Public Offering, January 2014	Additional paid in capital Public Offering, March 2015	Accumulated other comprehensive loss	Accumulated Deficit
Balance at Dec. 31, 2012	$ (3,408)									$ 1										$ 30,203										$ (33,612)
Balance (in shares) at Dec. 31, 2012										(8,952,905)
Consultants settlement (in shares)										181,500
Consultants settlement	1,180																			1,180
Incentive shares forfeited (in shares)											(20,833)	(37,500)
Treasury stock (in shares)																			(130,790)
Treasury stock	(957)																		$ (957)
Shares issued on behalf of related party (in shares)										11,000
Shares issued on behalf of related party	81																			81
Adjustment to existing shareholder (in shares)										5,333
Adjustment to existing shareholders	10																			10
Unrealized gain/(loss) on marketable securities	(110)																												$ (110)
Net income (loss)	(34,625)																													(34,625)
Share based payments (in shares)												177,500
Share based payments		$ 1,424	$ 1,485																		$ 1,424	$ 1,485
Issuance of common stock, net of fees (in shares)													272,221	3,045,929	5,531,401	291,907
Issuance of common stock, net of fees				$ 817	$ 2,441	$ 10,671	$ 1,324								$ 1								$ 817	$ 2,441	$ 10,670	$ 1,324
Issuance of common shares under the equity incentive plan											135,000
Balance at Dec. 31, 2013	(19,667)									$ 2									$ (957)	49,635									(110)	(68,237)
Balance (in shares) at Dec. 31, 2013										(18,546,363)									(130,790)
Treasury stock (in shares)										(248,801)									(248,801)
Treasury stock	(2,258)									$ (2,300)									$ (2,258)
Unrealized gain/(loss) on marketable securities	4,395																												4,395
Net income (loss)	(110,938)																													(110,938)
Share based payments (in shares)										730,774
Share based payments	16,639																			16,639
Kyalin Payments (in shares)										96,628
Kyalin payments	1,000																			1,000
Issuance of common stock, net of fees (in shares)																	4,705,882
Issuance of common stock, net of fees								$ 36,836									$ 1										$ 36,835
Exercise of warrants and reclassification of derivative liability (in shares)										1,947,377
Exercise of warrants and reclassification of derivative liability	31,762																			31,762
August 2013 private placement settlement	272																			272
Issuance of common stock to convertible debt holders (in shares)										401,047
Issuance of common stock to convertible debt holders	4,708																			4,708
Balance at Dec. 31, 2014	(37,251)									$ 3									$ (3,215)	140,851									4,285	(179,175)
Balance (in shares) at Dec. 31, 2014										(26,428,071)									(379,591)
Treasury stock (in shares)										0
Unrealized gain/(loss) on marketable securities	(4,927)																												(4,927)
Net income (loss)	117,237																													117,237
Share based payments	25,900																			25,900
Issuance of common stock, net of fees (in shares)																		7,866,000
Issuance of common stock, net of fees									$ 139,987									$ 1										$ 139,986
Exercise of warrants and reclassification of derivative liability (in shares)										870,306
Exercise of warrants and reclassification of derivative liability	28,012																			28,012
Retirement of treasury stock (in shares)										(379,591)									379,591
Shares issued in connection with Cholbam acquisition																			$ 3,215											(3,215)
Vesting of stock for accrued severance	2,126																			2,126
Foreign currency translation adjustments	(40)																												(40)
Option inducement liability reversal and adjustments	3,840																			3,840
Issuance of common shares under the equity incentive plan										478,334
Shares issued in connection with Cholbam acquisition (in shares)										661,279
Shares issued in connection with Cholbam acquisition	15,844																			15,844
Stock option exercises (in shares)										541,454
Stock option exercises	6,818																			6,818
Excess tax benefits of stock option exercises	2,425																			2,425
Balance at Dec. 31, 2015	$ 299,971									$ 4									$ 0	$ 365,802									$ (682)	$ (65,153)
Balance (in shares) at Dec. 31, 2015										(36,465,853)									0