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FAIR VALUE MEASUREMENTS (Tables)
12 Months Ended
Dec. 31, 2015
Fair Value Disclosures [Abstract]  
Schedule of fair value on a recurring basis
The following table presents the Company’s asset and liabilities that are measured and recognized at fair value on a recurring basis classified under the appropriate level of the fair value hierarchy as of December 31, 2015 (in thousands):
 
As of December, 2015
 
Fair Value Hierarchy at December 31, 2015
 
Total carrying and
estimated fair value
 
Quoted prices in
active markets
(Level 1)
 
Significant other
observable inputs
(Level 2)
 
Significant
unobservable
inputs (Level 3)
Asset:
 

 
 

 
 

 
 

Marketable securities, available-for-sale
$
191,799

 
$

 
$
191,799

 
$

Liabilities:
 

 
 

 
 

 
 

Derivative liability related to warrants
$
38,810

 
$

 
$

 
$
38,810

Business combination-related contingent consideration
$
59,021

 
$

 
$

 
$
59,021


The following table presents the Company’s asset and liabilities that are measured and recognized at fair value on a recurring basis classified under the appropriate level of the fair value hierarchy as of December 31, 2014 (in thousands):
 
As of December, 2014
 
Fair Value Hierarchy at December 31, 2014
 
Total carrying and
estimated fair value
 
Quoted prices in
active markets
(Level 1)
 
Significant other
observable inputs
(Level 2)
 
Significant
unobservable
inputs (Level 3)
Asset:
 

 
 

 
 

 
 

Marketable securities, available-for-sale
$
9,556

 
$
9,556

 
$

 
$

Liabilities:
 

 
 

 
 

 
 

Derivative liability related to warrants
$
27,990

 
$

 
$

 
$
27,990

Business combination-related contingent consideration
$
11,637

 
$

 
$

 
$
11,637

Schedule of fair value measurements of common stock warrants using significant unobservable inputs (Level 3)
The following table sets forth a summary of changes in the estimated fair value of the Company’s Level 3 derivative liability for the period from January 1, 2015 through December 31, 2015:
 
Fair Value Measurements of
Common Stock Warrants
Using Significant 
Unobservable Inputs (Level 3)
Balance at January 1, 2015
$
27,990

Issuance of common stock warrants
1,050

Reclassification of derivative liability to equity upon exercise of warrants
(23,537
)
Change in estimated fair value of liability classified warrants
33,307

Balance at December 31, 2015
$
38,810


The following table sets forth a summary of changes in the estimated fair value of the Company’s Level 3 derivative liability for the period from January 1, 2014 through December 31, 2014:
 
Fair Value Measurements of
Common Stock Warrants
Using Significant
Unobservable Inputs (Level 3)
Balance at January 1, 2014
$
25,037

Issuance of common stock warrants
2,531

Reclassification of derivative liability to equity upon exercise of warrants
(23,364
)
Change in estimated fair value of liability classified warrants
23,786

Balance at December 31, 2014
$
27,990

 
Schedule of fair value measurements of acquisition-related contingent consideration
The following table sets forth a summary of changes in the estimated business combination-related contingent consideration for the period from January 1, 2015 through December 31, 2015:
 
Fair Value Measurements
of
Acquisition-Related
Contingent Consideration
(Level 3)
Balance at January 1, 2015
$
11,637

Present value of contingent consideration related to Cholbam acquisition, upon acquisition
39,107

Increase from revaluation of contingent consideration
13,778

Decrease of contingent consideration, asset divestiture
(604
)
Contractual Payments
(3,938
)
Contractual Payments accrued at December 31, 2015
(959
)
Balance at December 31, 2015
$
59,021

The following table sets forth a summary of changes in the estimated acquisition-related contingent consideration for the period from January 1, 2014 through December 31, 2014:
 
Fair Value Measurements of
Acquisition-Related
Contingent Consideration
Balance at January 1, 2014
$

Present value of contingent consideration related to Manchester acquisition, upon acquisition
12,800

Contractual Payments
(1,163
)
Balance at December 31, 2014
$
11,637