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Income Taxes - Reconciliation of Statutory Federal Income Tax Rate to Effective Income Tax Rate (Detail) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Income Tax Disclosure [Abstract]      
Income taxes computed at statutory rates $ (8,834) $ (7,369) $ (6,081)
Increases (decreases) resulting from:      
State income taxes, net of federal tax benefit (1,576) (1,219) (1,298)
Impact of federal graduated rates 0 0 (4)
Federal and state research and experimentation credits (1,081) (1,112) (917)
Change in valuation allowance 1,216 9,468 8,132
Impact of expired tax positions 7 (41) 0
Impact of recent U.S. tax reform 10,529 0 0
Other (467) 283 234
Total tax provision (benefit) $ (206) $ 10 $ 66
Income taxes computed at statutory rates, Percentage 34.00% 34.00% 34.00%
Increases (decreases) resulting from:      
State income taxes, net of federal tax benefit, Percentage 6.00% 6.00% 7.00%
Impact of federal graduated rates, Percentage 0.00% 0.00% 0.00%
Federal and state research and experimentation credits, Percentage 4.00% 5.00% 5.00%
Change in valuation allowance, Percentage (5.00%) (44.00%) (45.00%)
Impact of expired tax positions, Percentage 0.00% 0.00% 0.00%
Impact of recent U.S. tax reform, Percentage (40.00%) 0.00% 0.00%
Other, Percentage 2.00% (1.00%) (1.00%)
Total, Percentage 1.00% 0.00% 0.00%