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Stockholders' Equity - Schedule of Assumptions Used in Black-Scholes Option-Pricing Model (Detail) - $ / shares
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Stock Options      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Weighted average grant date fair value (in dollars per share) $ 56.89 $ 54.20 $ 39.06
Risk-free interest rate 1.00% 0.60% 2.10%
Expected dividend yield 0.00% 0.00% 0.00%
Expected volatility 75.10% 74.60% 71.80%
Expected term (in years) 6 years 1 month 6 days 6 years 1 month 6 days 6 years
ESPP      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Weighted average grant date fair value (in dollars per share) $ 38.19 $ 36.83 $ 30.32
Risk-free interest rate 0.20% 0.20% 1.90%
Expected dividend yield 0.00% 0.00% 0.00%
Expected volatility 44.20% 60.30% 69.90%
Expected term (in years) 1 year 3 months 18 days 1 year 3 months 18 days 1 year 3 months 18 days