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License and Collaboration Agreements - Narrative (Details)
1 Months Ended 12 Months Ended
Oct. 31, 2016
USD ($)
payment
Dec. 31, 2015
USD ($)
Nov. 30, 2015
USD ($)
Dec. 31, 2017
USD ($)
license_agreement
Dec. 31, 2016
USD ($)
Dec. 31, 2015
USD ($)
Dec. 31, 2009
USD ($)
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Research and development       $ 43,670,000 $ 45,134,000 $ 33,087,000  
TheraVectys SA | Collaborative Arrangement | Maximum              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Potential future milestone payments $ 5,800,000            
Number of milestone payments waived | payment 2            
GLAAS Discovery Platform | Sanofi | Collaborative Arrangement, Product              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Milestone revenue recognized       0 7,000,000 1,000,000  
Milestone receivables       160,000,000      
GLAAS Discovery Platform | Infectious Disease Research Institute | Collaborative Arrangement              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Research and development     $ 250,000        
GLA | MedImmune LLC | Collaborative Arrangement, Product              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Milestone revenue recognized       0 0 2,500,000  
GLA | MedImmune LLC | Collaborative Arrangement, Product | Minimum              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Milestone receivables       62,900,000      
GLA | MedImmune LLC | Collaborative Arrangement, Product | Maximum              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Milestone receivables       72,500,000      
GLA | Infectious Disease Research Institute | Collaborative Arrangement              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Milestone revenue recognized       0 925,000 2,900,000  
First GLAAS Discovery Platform Product | Infectious Disease Research Institute | Collaborative Arrangement              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Potential future milestone payments       250,000      
Subsequent GLAAS Discovery Platform Products | Infectious Disease Research Institute | Collaborative Arrangement              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Potential future milestone payments       125,000      
GLA/SLA Product | Infectious Disease Research Institute | Collaborative Arrangement              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Research and development   $ 2,300,000          
GLA/SLA First Exclusive Product | Infectious Disease Research Institute | Collaborative Arrangement | Maximum              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Potential future milestone payments       2,300,000      
GLA/SLA Subsequent Exclusive Products | Infectious Disease Research Institute | Collaborative Arrangement | Maximum              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Potential future milestone payments       1,300,000      
GLA/SLA First Non-Exclusive Product | Infectious Disease Research Institute | Collaborative Arrangement | Maximum              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Potential future milestone payments       1,300,000      
GLA/SLA Subsequent Non-Exclusive Products | Infectious Disease Research Institute | Collaborative Arrangement | Maximum              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Potential future milestone payments       625,000      
Dendritic Cell-targeted Theraputic and Prophylactic Immunization Strategies | California Institute of Technology | Collaborative Arrangement              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Milestone revenue recognized       $ 100,000 0 0  
Number of license agreements | license_agreement       2      
Annual license fee             $ 25,000
Dendritic Cell-targeted Theraputic and Prophylactic Immunization Strategies | California Institute of Technology | Collaborative Arrangement | Common stock              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Value of common stock issued for license             $ 25,000
Dendritic Cell-targeted Theraputic and Prophylactic Immunization Strategies | California Institute of Technology | Collaborative Arrangement | Maximum              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Potential future milestone payments       $ 1,500,000      
Herpes Simplex Virus | Sanofi Pasteur | Collaborative Arrangement, Product              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Unbilled receivable       605,000 0    
Unearned receivable       0 2,500,000    
Herpes Simplex Virus | Sanofi Pasteur | Collaborative Arrangement, Product | Collaboration Revenue              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Milestone revenue recognized       $ 6,900,000 $ 4,600,000 $ 4,200,000