144 0002044416 XXXXXXXX LIVE 0001437402 ARDELYX, INC. 001-36485 400 Fifth Avenue, Suite 210 Waltham MA 02451 617-675-2739 Reilly Joseph James Officer Common Stock Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza, 8th Floor New York NY 10004

4700 29281.00 247029387 05/19/2026 NASDAQ Common Stock 05/19/2026 Vesting of restricted stock units Issuer N 10388 05/19/2026 Services Rendered N Joseph James Reilly

400 Fifth Avenue, Suite 210 Waltham MA 02451

Common Stock 02/20/2026 4387 25729.76 Joseph James Reilly

400 Fifth Avenue, Suite 210 Waltham MA 02451

Common Stock 02/20/2026 602 3439.71 Joseph James Reilly

400 Fifth Avenue, Suite 210 Waltham MA 02451

Common Stock 02/20/2026 2 11.40 Pursuant to an automatic sell-to-cover imposed by the terms of the initial grant of the restricted stock units (RSUs) awards, the shares are to be sold upon the vesting of the RSUs solely to cover applicable withholding taxes. 05/19/2026 Michael Raab, as Attorney-in-Fact for Joseph James Reilly