XML 26 R12.htm IDEA: XBRL DOCUMENT v3.25.2
COLLABORATION AND LICENSING AGREEMENTS
 6 Months Ended
Jun. 30, 2025
Collaboration and Licensing Agreements  
COLLABORATION AND LICENSING AGREEMENTS COLLABORATION AND LICENSING AGREEMENTS
We out-license to external partners for the development of tenapanor and commercialization of tenapanor outside of the U.S. We recognize revenue from our agreements with Kyowa Kirin, Fosun Pharma and Knight as licensing revenue, product supply revenue or non-cash royalty revenue related to the sale of future royalties. See Note 7. Collaboration and Licensing Agreements and “Licensing Revenue Recognition” caption of Note 2. Summary of Significant Accounting Policies of our 2024 Form 10-K for more information on the nature, purpose, significant rights and obligations of the parties, as well as our accounting policies for such revenue streams.
The following table summarizes total revenues by collaboration partner:
Three Months Ended June 30,Six Months Ended June 30,
(in thousands)2025202420252024
Licensing revenue
Fosun Pharma
$— $— $5,000 $— 
Knight
20 19 40 36 
Total licensing revenue
$20 $19 $5,040 $36 
Product supply revenue   
Kyowa Kirin
$6,185 $13 $6,185 $2,139 
Knight
— — 254 — 
Total supply revenue
$6,185 $13 $6,439 $2,139 
Non-cash royalty revenue related to the sale of future royalties   
Kyowa Kirin
$1,380 $599 $2,406 $967 
The following table presents changes in our current and non-current deferred revenue balances, which are all attributable to Kyowa Kirin:
20252024
(in thousands)CurrentNon-CurrentCurrentNon-Current
Deferred revenue balance as of January 1,
$10,686$7,232$7,182$8,644
Prepaid product supply2275,0637315,213
Product supply delivered(4,633)—(1,328)—
Reclassify amounts to be recognized in the next twelve months——4,244(4,244)
Deferred revenue balance as of June 30,$6,280$12,295$10,829$9,613
Significant developments and updates related to our collaboration and licensing agreements in the six months ended June 30, 2025 and 2024 are discussed below.
Kyowa Kirin
In February 2024, Kyowa Kirin announced the launch of tenapanor, marketed as PHOZEVEL®, for patients with CKD with hyperphosphatemia in Japan. In the three months ended March 31, 2024, we began to recognize non-cash royalty revenue related to the sale of future royalties, which was remitted to HCR in accordance with the HCR Agreement.
Fosun Pharma
In February 2025, we announced the approval of an NDA for tenapanor for the control of hyperphosphatemia in adult patients with CKD undergoing hemodialysis by China’s Center for Drug Evaluation of the NMPA. This approval triggered a $5.0 million milestone to us under the terms of the Fosun Agreement, which was recorded as licensing revenue on our condensed statement of operations and comprehensive loss when earned during the 2025 first quarter and was received in April 2025.
AstraZeneca
In connection with the AstraZeneca Termination Agreement, we recognized royalty expense as other cost of revenue in our condensed statements of operations and comprehensive loss of $3.8 million and $12.7 million in the three and six months ended June 30, 2025, and $7.9 million and $12.6 million in the three and six months ended June 30, 2024, respectively. As of June 30, 2025, we have fully recognized the $75.0 million royalty obligation.