CONDENSED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022
Operating activities
Net loss	$ (43,894)	$ (55,009)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization expense	639	738
Non-cash lease expense	1,821	1,698
Stock-based compensation	6,111	6,976
Gain on sale of equipment	0	(853)
Non-cash interest expense	2,090	151
Other, net	(521)	136
Changes in operating assets and liabilities:
Accounts receivable	(1,376)	(5,121)
Inventory	(19,566)	(4,529)
Prepaid commercial manufacturing	401	(12,197)
Prepaid expenses and other assets	817	1,848
Accounts payable	(5,565)	17
Accrued compensation and benefits	(668)	983
Operating lease liabilities	(1,892)	(1,692)
Accrued and other liabilities	110	259
Deferred revenue	1,961	7,694
Net cash used in operating activities	(59,532)	(58,901)
Investing activities
Proceeds from maturities and redemptions of investments	19,250	42,300
Purchases of investments	(88,127)	(25,762)
Proceeds from sale of property and equipment	0	1,268
Purchases of property and equipment	(107)	0
Net cash (used in) provided by investing activities	(68,984)	17,806
Financing activities
Proceeds from 2022 Loan, net of issuance costs	0	26,971
Payments for 2018 Loan, net of costs	0	(33,038)
Proceeds from the sale of future royalties, net of issuance costs	0	9,581
Proceeds from issuance of common stock in at the market offering, net of issuance costs	62,085	18,478
Proceeds from issuance of common stock under equity incentive and stock purchase plans	349	83
Net cash provided by financing activities	62,434	22,075
Net decrease in cash and cash equivalents	(66,082)	(19,020)
Cash and cash equivalents at beginning of period	96,140	72,428
Cash and cash equivalents at end of period	30,058	53,408
Supplementary disclosure of cash flow information:
Cash paid for interest	1,757	1,360
Cash paid for income taxes	19	6
Supplementary disclosure of non-cash activities:
Issuance of common stock for services	337	0
Issuance of derivative in connection with issuance of loan payable	$ 0	$ 375