Collaboration and Licensing Agreements - Narrative (Details) $ in Millions, ¥ in Billions	1 Months Ended					12 Months Ended				50 Months Ended	91 Months Ended
	Nov. 30, 2019 USD ($) item segment	Mar. 31, 2018 USD ($)	Dec. 31, 2017 USD ($)	Nov. 30, 2017 USD ($)	Jun. 30, 2015 USD ($)	Dec. 31, 2022 USD ($)	Dec. 31, 2022 CAD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2022 USD ($)	Dec. 31, 2022 JPY (¥)	Oct. 31, 2022 USD ($)	Apr. 30, 2022 USD ($) payment_tranche
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Total revenues						$ 52,158,000		$ 10,097,000	$ 7,571,000
Deferred revenue						4,211,000		0		$ 0	$ 4,211,000
Cost of revenue						4,117,000		1,000,000	145,000
Licensing revenue
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Total revenues						35,031,000		5,013,000	706,000
Product supply revenue
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Total revenues						1,527,000		907,000	1,501,000
2019 KKC Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Total revenues						0		4,200,000
Deferred revenue						0		0	$ 4,177,000	0	0
2017 KKC Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Deferred revenue						4,211,000		0		0	4,211,000
2017 KKC Agreement | Licensing revenue
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Total revenues						35,000,000		5,000,000		$ 20,000,000
2017 KKC Agreement | Product supply revenue
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Total revenues						1,500,000		900,000
Fosun Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Total revenues						0		0
Knight Agreement | Licensing revenue
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Total revenues						31,000		13,000
Knight Agreement | Product supply revenue
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Total revenues						0		0
Kyowa Kirin Co. Ltd | 2019 KKC Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Upfront license fees	$ 10,000,000
First installment of upfront license fees	$ 5,000,000
Term of payment of license fee, first installment	30 days
Second installment of upfront license fees	$ 5,000,000
Term of agreement	2 years
Number of amendments | segment	3
Kyowa Kirin Co. Ltd | 2019 KKC Agreement | Minimum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Number of separate collaborative agreements | item	1
Kyowa Kirin Co. Ltd | 2017 KKC Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Upfront license fees				$ 30,000,000
Potential development milestones				$ 55,000,000
Potential commercialization milestones						64,600,000					64,600,000	¥ 8.5
Fee receivable for reduction in royalty rate														$ 40,000,000
Number of payment tranches for fee receivable for reduction in royalty rate | payment_tranche														2
Kyowa Kirin Co. Ltd | 2017 KKC Agreement | Licensing revenue
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Proceeds from milestone payments													$ 35,000,000
Fosun Pharma | Fosun Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Upfront payment received			$ 12,000,000
Potential development and commercialization milestones						$ 110,000,000
Threshold percentage of net sales for tiered royalties						20.00%	20.00%
Knight | Knight Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Upfront payment received		$ 2,300,000
Potential development and commercialization milestones						$ 16,300,000	$ 22.2
AstraZeneca | AZ Termination Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Percentage of royalty revenue					10.00%
Percentage of non royalty revenue					20.00%
Maximum potential payment per agreement					$ 75,000,000
Cost of revenue						$ 3,600,000		$ 1,000,000			$ 15,300,000