CONDENSED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Operating activities
Net loss	$ (55,009)	$ (78,344)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation expense	407	787
Amortization of deferred financing costs	226	316
Amortization of deferred compensation for services	105	145
Amortization of premium on investment securities	16	274
Non-cash lease expense	1,698	1,318
Stock-based compensation	6,976	6,306
Change in derivative liabilities	18	(713)
Debt refinancing costs	102	0
Gain on sale of equipment	(853)	0
Non-cash interest associated with debt discount accretion	151	141
Changes in operating assets and liabilities:
Accounts receivable	(5,121)	0
Inventory	(4,529)	0
Prepaid commercial manufacturing	(12,197)	(8,481)
Prepaid expenses and other assets	1,848	1,102
Accounts payable	17	(3,039)
Accrued compensation and benefits	983	267
Operating lease liabilities	(1,692)	(1,361)
Accrued and other liabilities	259	2,607
Deferred revenue	7,694	182
Net cash used in operating activities	(58,901)	(78,493)
Investing activities
Proceeds from maturities and redemptions of investments	42,300	60,550
Purchases of investments	(25,762)	(48,314)
Proceeds from sale of property and equipment	1,268	0
Purchases of property and equipment	0	(1,517)
Net cash provided by investing activities	17,806	10,719
Financing activities
Proceeds from 2022 Loan, net of issuance costs	26,971	0
Repayment of 2018 Loan, net of settlement costs	(33,038)	0
Proceeds from the sale of future royalties, net of issuance costs	9,581	0
Proceeds from issuance of common stock in at the market offering, net of issuance costs	18,478	62,446
Proceeds from issuance of common stock under equity incentive and stock purchase plans	83	1,041
Net cash provided by financing activities	22,075	63,487
Net decrease in cash and cash equivalents	(19,020)	(4,287)
Cash and cash equivalents at beginning of period	72,428	91,032
Cash and cash equivalents at end of period	53,408	86,745
Supplementary disclosure of cash flow information:
Cash paid for interest	1,360	1,936
Cash paid for income taxes	6	3
Supplementary disclosure of non-cash activities:
Right-of-use assets obtained in exchange for lease obligations	0	14,379
Issuance of derivative in connection with issuance of loan payable	$ 375	$ 0