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Cost of revenue, aggregate amount recognized.

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Represents percentage of non-royalty revenue.

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Represents percentage of royalty revenue.

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Revenue, General Payment Terms

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Amount, after allowance for credit loss, of right to consideration from customer for product sold and service rendered in normal course of business, classified as current.

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- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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Sum of investments and unrestricted cash as of the balance sheet date.

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Number of operating segments. An operating segment is a component of an enterprise: (a) that engages in business activities from which it may earn revenues and incur expenses (including revenues and expenses relating to transactions with other components of the same enterprise), (b) whose operating results are regularly reviewed by the enterprise's chief operating decision maker to make decisions about resources to be allocated to the segment and assess its performance, and (c) for which discrete financial information is available. An operating segment may engage in business activities for which it has yet to earn revenues, for example, start-up operations may be operating segments before earning revenues.

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The cumulative amount of the reporting entity's undistributed earnings or deficit.

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Organization and Basis of Presentation (Details) $ in Thousands	1 Months Ended	3 Months Ended
	Jun. 30, 2015 USD ($)	Mar. 31, 2022 USD ($) segment	Dec. 31, 2021 USD ($)
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Number of segments \| segment		1
Cash and investments		$ 89,704	$ 116,689
Accumulated deficit		(741,001)	(712,930)
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Accounts receivable		4,394	502
Collaborators
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Accounts receivable		3,800	$ 500
Commercial customers
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Accounts receivable		$ 600
Minimum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Payment terms		30 days
Maximum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Payment terms		60 days
AstraZeneca
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Aggregate cost of revenue recognized		$ 11,700
AstraZeneca \| AZ Termination Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Percentage of royalty revenue	10.00%
Percentage of non-royalty revenue	20.00%
Maximum potential payment per agreement	$ 75,000