X0508 4 2025-11-21 0001437402 ARDELYX, INC. ARDX 0001213041 GRAMMER ELIZABETH A C/O ARDELYX, INC. 400 FIFTH AVENUE, SUITE 210 WALTHAM MA 02451 true See Remarks false Common Stock 2025-11-21 4 S 0 5995 5.5369 D 299895 D Pursuant to an automatic sell-to-cover imposed by the terms of the initial grant of the restricted stock units ("RSUs") awards, the shares were sold upon the vesting of the RSUs solely to cover applicable withholding taxes. Chief Legal and Administrative Officer /s/ Elizabeth Grammer 2025-11-25