X0206 3 2025-08-01 0 0001437402 ARDELYX, INC. ARDX 0001308911 Bishop John E C/O ARDELYX, INC. 400 FIFTH AVENUE, SUITE 210 WALTHAM MA 02451 true See Remarks Common Stock 218000 D Stock Option (Right to Buy) 4.49 2035-07-14 Common Stock 327000 D Restricted stock units ("RSUs"). The Reporting Person is entitled to receive one (1) shares of Common Stock for each one (1) RSU upon the vesting thereof. Twenty Five Percent (25%) of the shares subject to the option vest on July 14, 2026 and the remaining shares subject to the option vest in 36 successive, equal monthly installments thereafter, subject to the Reporting Person's continued employment or service relationship with the Issuer on each such vesting date. Chief Technical Operations Officer Exhibit 24.1 - Power of Attorney /s/ Elizabeth Grammer, Attorney-in-Fact for John Bishop 2025-10-17