X0306 4 2022-06-15 0 0001437402 ARDELYX, INC. ARDX 0001480120 Lundberg Jan M C/O ARDELYX, INC. 400 FIFTH AVENUE, SUITE 210 WALTHAM MA 02451 1 0 0 0 Common Stock 2022-06-15 4 A 0 91240 0.00 A 134039 D Stock Option (Right to Buy) 0.5480 2022-06-15 4 A 0 100000 0.00 A 2032-06-15 Common Stock 100000 100000 D The shares were issued pursuant to the Issuer's Non-Employee Director Compensation Program. The Reporting Person elected to receive stock in lieu of cash as permitted under the program. The option was issued pursuant to the Issuer's Non-Employee Director Compensation Program. The option vests with respect to 1/12th of the shares subject thereto on each monthly anniversary of the grant date, which vesting will accelerate in full on the date of the next annual stockholder's meeting to the extent unvested as of such date, subject to continued service through each applicable vesting date. /s/ Elizabeth Grammer, Attorney-in-Fact for Jan M. Lundberg 2022-06-17