X0306 4 2022-06-06 0 0001437402 ARDELYX, INC. ARDX 0001611311 Rosenbaum David P. C/O ARDELYX, INC. 400 FIFTH AVENUE, SUITE 210 WALTHAM MA 02451 0 1 0 0 Chief Development Officer Common Stock 2022-06-06 4 S 0 43093 0.6509 D 304827 D Common Stock 2022-06-06 4 S 0 911 0.6357 D 303916 D Common Stock 2022-06-06 4 S 0 17270 0.6509 D 90232 I By Wife Common Stock 2022-06-06 4 S 0 366 0.6357 D 89866 I By Wife Common Stock 77592 I Family Trust Pursuant to an automatic sell-to-cover imposed by the terms of the initial grant of the restricted stock units ("RSUs") awards, the shares were sold upon the vesting of the RSUs solely to cover applicable withholding taxes. The shares are directly held by the Reporting Person's wife. The shares are directly held by David Paul Rosenbaum and Susan Edelstein Rosenbaum, Trustees of the David Paul Rosenbaum Family Trust. /s/ Elizabeth Grammer, Attorney-in-Fact for David Rosenbaum 2022-06-08