X0306 4 2022-01-06 0 0001437402 ARDELYX, INC. ARDX 0001812511 Rodriguez Susan C/O ARDELYX, INC. 34175 ARDENWOOD BLVD FREMONT CA 94555 0 1 0 0 Chief Commercial Officer Common Stock 2022-01-06 4 A 0 141000 0 A 338031 D Stock Option (Right to Buy) 0.99 2022-01-06 4 A 0 195000 0.00 A 2032-01-06 Common Stock 195000 195000 D Restricted stock units ("RSUs"). The Reporting Person is entitled to receive one (1) shares of Common Stock for each one (1) RSU upon the vesting thereof. The option becomes exercisable as it vests and the shares subject to the option vest in 48 successive, equal monthly installments on each monthly anniversary of January 6, 2022, subject to the Reporting Person's continued employment or service relationship with the Issuer on each such vesting date. Total was adjusted by one share as the last report reflected an incorrect amount of shares sold. /s/ Elizabeth Grammer, Attorney-in-Fact for Susan Rodriguez 2022-01-12