X0306 4 2020-06-24 0 0001437402 ARDELYX, INC. ARDX 0001219871 MOTT DAVID M C/O ARDELYX, INC. 34175 ARDENWOOD BLVD FREMONT CA 94555 1 0 0 0 Common Stock 2020-06-24 4 P 0 72598 6.7476 A 178911 D Common Stock 2020-06-25 4 P 0 68373 6.9624 A 247284 D This transaction was executed in multiple trades in prices ranging from $6.65 to $7.00, inclusive. The price reported in Column 4 above reflects the weighted average sales price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. This transaction was executed in multiple trades in prices ranging from $6.83 to $7.00, inclusive. The price reported in Column 4 above reflects the weighted average sales price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. The Reporting Person holds 87,566 shares for the benefit of entities associated with New Enterprise Associates and disclaims beneficial ownership of such shares, except to the extent of his actual pecuniary interest therein. /s/ Elizabeth Grammer, Attorney-in-Fact for David Mott 2020-06-26