Accrued and Other Liabilities - Schedule of Accrued Liabilities and Other Liabilities (Details) - USD ($) $ in Thousands	Jun. 30, 2019	Dec. 31, 2018
Accrued and Other Liabilities
Accrued clinical and non-clinical expenses	$ 7,697	$ 9,790
Accrued contract manufacturing expenses	1,622	1,971
Derivative liability for exit fee	594	533
Accrued professional and consulting services	269	112
Foreign currency derivative contract		52
Other	222	399
Accrued liabilities and other liabilities	$ 10,404	$ 12,857	[1]

[1] Derived from the audited consolidated financial statements included in the Company’s Annual Report on Form 10K for the year ended December 31, 2018.