Accrued and Other Liabilities - Schedule of Accrued Liabilities and Other Liabilities (Detail) - USD ($) $ in Thousands	Sep. 30, 2018	Dec. 31, 2017
Accrued and Other Liabilities
Accrued clinical and non-clinical expenses	$ 6,792	$ 5,447
Accrued contract manufacturing expenses	977	3,980
Accrued professional and consulting services	627	530
Derivative liability for exit fee	556
Foreign currency derivative contract	46
Other	976	752
Accrued liabilities and other liabilities	$ 9,974	$ 10,709	[1]

[1] Derived from the audited consolidated financial statements included in the Company’s Annual Report on Form 10K for the year ended December 31, 2017.