144 0001466562 XXXXXXXX LIVE 0001437402 ARDELYX, INC. 001-36485 400 Fifth Avenue, Suite 210 Waltham MA 02451 510-745-1700 Renz Justin A Former Officer Common Stock Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza, 8th Floor New York NY 10004

49040 272172.00 242974306 11/24/2025 NASDAQ Common Stock 11/19/2025 Vesting of restricted stock units Issuer N 109635 11/19/2025 Services Rendered Y Pursuant to an automatic sell-to-cover imposed by the terms of the initial grant of the restricted stock units (RSUs) awards, the shares are to be sold upon the vesting of the RSUs solely to cover applicable withholding taxes. 11/24/2025 Elizabeth Grammer, as Attorney-in-Fact for Justin A. Renz