<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001321402</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001437402</issuerCik>
      <issuerName>ARDELYX, INC.</issuerName>
      <secFileNumber>001-36485</secFileNumber>
      <issuerAddress>
        <com:street1>400 Fifth Avenue, Suite 210</com:street1>
        <com:city>Waltham</com:city>
        <com:stateOrCountry>MA</com:stateOrCountry>
        <com:zipCode>02451</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>617 675-2739</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>RAAB MICHAEL</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
        <address>
          <com:street1>1 New York Plaza, 8th Floor</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10004</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>44500</noOfUnitsSold>
      <aggregateMarketValue>179335.00</aggregateMarketValue>
      <noOfUnitsOutstanding>249187572</noOfUnitsOutstanding>
      <approxSaleDate>08/21/2026</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>08/19/2026</acquiredDate>
      <natureOfAcquisitionTransaction>Vesting of restricted stock units</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>108840</amountOfSecuritiesAcquired>
      <paymentDate>08/19/2026</paymentDate>
      <natureOfPayment>Services Rendered</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Michael Raab</name>
        <address>
          <com:street1>400 Fifth Avenue, Suite 210</com:street1>
          <com:city>Waltham</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02451</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>05/21/2026</saleDate>
      <amountOfSecuritiesSold>14933</amountOfSecuritiesSold>
      <grossProceeds>93592.58</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Michael Raab</name>
        <address>
          <com:street1>400 Fifth Avenue, Suite 210</com:street1>
          <com:city>Waltham</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02451</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>05/21/2026</saleDate>
      <amountOfSecuritiesSold>7861</amountOfSecuritiesSold>
      <grossProceeds>49268.82</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Michael Raab</name>
        <address>
          <com:street1>400 Fifth Avenue, Suite 210</com:street1>
          <com:city>Waltham</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02451</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>05/21/2026</saleDate>
      <amountOfSecuritiesSold>17926</amountOfSecuritiesSold>
      <grossProceeds>112351.21</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Michael Raab</name>
        <address>
          <com:street1>400 Fifth Avenue, Suite 210</com:street1>
          <com:city>Waltham</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02451</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>05/21/2026</saleDate>
      <amountOfSecuritiesSold>14028</amountOfSecuritiesSold>
      <grossProceeds>87920.49</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Michael Raab</name>
        <address>
          <com:street1>400 Fifth Avenue, Suite 210</com:street1>
          <com:city>Waltham</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02451</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>06/15/2026</saleDate>
      <amountOfSecuritiesSold>41666</amountOfSecuritiesSold>
      <grossProceeds>236346.22</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Michael Raab</name>
        <address>
          <com:street1>400 Fifth Avenue, Suite 210</com:street1>
          <com:city>Waltham</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02451</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>07/15/2026</saleDate>
      <amountOfSecuritiesSold>41668</amountOfSecuritiesSold>
      <grossProceeds>210923.42</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>The transaction dated June 15, 2026 reflects the weighted average sale price, with sales prices ranging from $5.625 to $5.77, inclusive. The gross proceeds was calculated using a weighted average sales price of $5.6724. The transaction dated July 15, 2026 reflects the weighted average sale price, with sales prices ranging from $5.03 to $5.12, inclusive. The gross proceeds was calculated using a weighted average sales price of $5.062. Pursuant to an automatic sell-to-cover imposed by the terms of the initial grant of the restricted stock units (RSUs) awards, the shares are to be sold upon the vesting of the RSUs solely to cover applicable withholding taxes.</remarks>
    <noticeSignature>
      <noticeDate>08/21/2026</noticeDate>
      <signature>Orlando Wells</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
