144 0001308911 XXXXXXXX LIVE 0001437402 ARDELYX, INC. 001-36485 400 Fifth Avenue, Suite 210 Waltham MA 02451 617-675-2739 Bishop John E Officer Common Stock Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza, 8th Floor New York NY 10004

3700 23051.00 247029387 05/19/2026 NASDAQ Common Stock 05/19/2026 Vesting of restricted stock units Issuer N 7771 05/19/2026 Services Rendered N John E. Bishop

400 Fifth Avenue, Suite 210 Waltham MA 02451

Common Stock 02/20/2026 2792 16375.08 John E. Bishop

400 Fifth Avenue, Suite 210 Waltham MA 02451

Common Stock 02/20/2026 386 2205.53 John E. Bishop

400 Fifth Avenue, Suite 210 Waltham MA 02451

Common Stock 02/20/2026 1 5.70 Pursuant to an automatic sell-to-cover imposed by the terms of the initial grant of the restricted stock units (RSUs) awards, the shares are to be sold upon the vesting of the RSUs solely to cover applicable withholding taxes. 05/19/2026 Michael Raab, as Attorney-in-Fact for John E. Bishop