X0306 4 2016-01-13 0 0001437402 ARDELYX, INC. ARDX 0001219855 BARRETT M JAMES 1954 GREENSPRING DRIVE SUITE 600 TIMONIUM MD 21093 0 0 1 0 Common Stock 2016-01-13 4 P 0 500000 10.00 A 7988893 I See Note 2 Reports the purchase of shares in the underwritten public offering of common stock of Ardelyx, Inc. The Reporting Person is a manager of NEA 12 GP, LLC, ("NEA 12 GP") which is the sole general partner of NEA Partners 12, Limited Partnership ("NEA Partners 12"). NEA Partners 12 is the sole general partner of New Enterprise Associates 12, Limited Partnership ("NEA 12"), the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the securities held by NEA 12 in which the Reporting Person has no pecuniary interest. /s/ Sasha Keough, attorney-in-fact 2016-01-14