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Pay vs Performance Disclosure - USD ($)

12 Months Ended

Dec. 31, 2024

Dec. 31, 2023

Dec. 31, 2022

Dec. 31, 2021

Pay vs Performance Disclosure

Pay vs Performance Disclosure, Table

Pay Versus Performance

Pay Versus Performance Table

The following table sets forth information concerning the compensation provided to our NEOs and certain measures of Company performance in the years ended December 31, 2024, 2023, 2022 and 2021, for services to our Company in all capacities. The Compensation Committee did not consider the pay versus performance disclosure below in making its pay decisions for any of the fiscal years shown.


Year			Summary Compensation Table Total for PEO ($)			Compensation Actually Paid to PEO ($)⁽¹⁾			Average Summary Compensation Table Total for Non-PEO NEOs ($)			Average Compensation Actually Paid to Non-PEO NEOs ($)⁽¹⁾			Value of Initial Fixed $100 Investment Based on Total Shareholder Return (“TSR”) ($)⁽²⁾			Peer Group TSR ($)⁽³⁾			Net Loss ($ in millions)			Total Revenue ($ in millions)⁽⁴⁾
2024			9,606,165			4,749,620			2,941,814			1,676,438			78			105			(39)			334
2023			4,113,194			10,055,709			1,626,676			3,344,278			96			101			(66)			124
2022			1,947,020			4,047,941			1,049,800			1,913,762			44			103			(67)			52
2021			4,230,994			39,202			1,700,013			584,783			17			92			(158)			10

(1)

Amounts represent compensation actually paid (“CAP”) to our CEO, Michael Raab, who was our Principal Executive Officer or “PEO” for each of the four years shown, and the average CAP to our remaining NEOs or “Non-PEO NEOs” for the relevant fiscal year, as determined under SEC rules, which includes Justin Renz, Elizabeth Grammer, Esq., Laura Williams, M.D., M.P.H., and Michael Kelliher for 2024, Laura Williams, M.D., M.P.H and Elizabeth Grammer, Esq. for 2023, Laura Williams, M.D., M.P.H. and Susan Rodriguez for 2022 and Justin Renz, Robert Blanks, Elizabeth Grammer, Esq. and David Rosenbaum, Ph.D. for 2021.

Amounts represent the Summary Compensation Table Total Compensation for the applicable fiscal year adjusted as follows:


Fiscal Year (“FY”)			2024
			PEO ($)			Average non- PEO NEOs ($)
2024 Summary Compensation Table Total			9,606,165			2,941,814
Deduction for ASC 718 Fair Value as of Grant Date Reported under the Option Awards Columns in the Summary Compensation Table			8,335,121			2,264,081
Increase based on ASC 718 Fair Value of Awards Granted during the FY that Remain Unvested as of FY End (“FYE”)			2,972,646			919,554
Increase based on ASC 718 Fair Value of Awards Granted during the FY that Vested during the FY as of Vesting Date			1,251,140			247,178
Increase/deduction based on ASC 718 Fair Value of Outstanding Unvested Prior FY Awards as of FYE Compared to Valuation as of Prior FYE			(1,245,555)			(282,833)
Increase/deduction based on ASC 718 Fair Value of Prior FY Awards that Vested during the FY as of Vesting Date Compared to Valuation as of Prior FYE			500,345			114,805
Total Adjustments			(4,856,545)			(1,265,377)
Compensation Actually Paid			4,749,620			1,676,438

(2)

Cumulative TSR is calculated by dividing the sum of the cumulative amount of dividends for the measurement period, assuming dividend reinvestment, and the difference between our company’s share price at the end and the beginning of the measurement period by our company’s share price at the beginning of the measurement period. No dividends were paid on our common stock in 2021, 2022, 2023 or 2024.

(3)

Represents the weighted peer group TSR, weighted according to the respective companies' stock market capitalization at the beginning of each period for which a return is indicated. The peer group used for this purpose is the same peer group used in the review of our executive compensation, as disclosed under “Compensation Discussion and Analysis”. Please refer to “Use of Market Data” caption of the “Compensation Discussion and Analysis” for the names of the peer group companies.

(4)	We have selected total revenue as the most important financial measure used by us to link compensation actually paid for 2024 to our performance since it is the financial measure with the largest impact on the cash bonuses we pay our NEOs.

Company Selected Measure Name

total revenue

Named Executive Officers, Footnote

(1)

Amounts represent compensation actually paid (“CAP”) to our CEO, Michael Raab, who was our Principal Executive Officer or “PEO” for each of the four years shown, and the average CAP to our remaining NEOs or “Non-PEO NEOs” for the relevant fiscal year, as determined under SEC rules, which includes Justin Renz, Elizabeth Grammer, Esq., Laura Williams, M.D., M.P.H., and Michael Kelliher for 2024, Laura Williams, M.D., M.P.H and Elizabeth Grammer, Esq. for 2023, Laura Williams, M.D., M.P.H. and Susan Rodriguez for 2022 and Justin Renz, Robert Blanks, Elizabeth Grammer, Esq. and David Rosenbaum, Ph.D. for 2021.

Peer Group Issuers, Footnote

(3)

Represents the weighted peer group TSR, weighted according to the respective companies' stock market capitalization at the beginning of each period for which a return is indicated. The peer group used for this purpose is the same peer group used in the review of our executive compensation, as disclosed under “Compensation Discussion and Analysis”. Please refer to “Use of Market Data” caption of the “Compensation Discussion and Analysis” for the names of the peer group companies.

PEO Total Compensation Amount

$ 9,606,165

$ 4,113,194

$ 1,947,020

$ 4,230,994

PEO Actually Paid Compensation Amount

$ 4,749,620

10,055,709

4,047,941

39,202

Adjustment To PEO Compensation, Footnote

Amounts represent the Summary Compensation Table Total Compensation for the applicable fiscal year adjusted as follows:


Fiscal Year (“FY”)			2024
			PEO ($)			Average non- PEO NEOs ($)
2024 Summary Compensation Table Total			9,606,165			2,941,814
Deduction for ASC 718 Fair Value as of Grant Date Reported under the Option Awards Columns in the Summary Compensation Table			8,335,121			2,264,081
Increase based on ASC 718 Fair Value of Awards Granted during the FY that Remain Unvested as of FY End (“FYE”)			2,972,646			919,554
Increase based on ASC 718 Fair Value of Awards Granted during the FY that Vested during the FY as of Vesting Date			1,251,140			247,178
Increase/deduction based on ASC 718 Fair Value of Outstanding Unvested Prior FY Awards as of FYE Compared to Valuation as of Prior FYE			(1,245,555)			(282,833)
Increase/deduction based on ASC 718 Fair Value of Prior FY Awards that Vested during the FY as of Vesting Date Compared to Valuation as of Prior FYE			500,345			114,805
Total Adjustments			(4,856,545)			(1,265,377)
Compensation Actually Paid			4,749,620			1,676,438

Non-PEO NEO Average Total Compensation Amount

$ 2,941,814

1,626,676

1,049,800

1,700,013

Non-PEO NEO Average Compensation Actually Paid Amount

$ 1,676,438

3,344,278

1,913,762

584,783

Adjustment to Non-PEO NEO Compensation Footnote

Amounts represent the Summary Compensation Table Total Compensation for the applicable fiscal year adjusted as follows:


Fiscal Year (“FY”)			2024
			PEO ($)			Average non- PEO NEOs ($)
2024 Summary Compensation Table Total			9,606,165			2,941,814
Deduction for ASC 718 Fair Value as of Grant Date Reported under the Option Awards Columns in the Summary Compensation Table			8,335,121			2,264,081
Increase based on ASC 718 Fair Value of Awards Granted during the FY that Remain Unvested as of FY End (“FYE”)			2,972,646			919,554
Increase based on ASC 718 Fair Value of Awards Granted during the FY that Vested during the FY as of Vesting Date			1,251,140			247,178
Increase/deduction based on ASC 718 Fair Value of Outstanding Unvested Prior FY Awards as of FYE Compared to Valuation as of Prior FYE			(1,245,555)			(282,833)
Increase/deduction based on ASC 718 Fair Value of Prior FY Awards that Vested during the FY as of Vesting Date Compared to Valuation as of Prior FYE			500,345			114,805
Total Adjustments			(4,856,545)			(1,265,377)
Compensation Actually Paid			4,749,620			1,676,438

Compensation Actually Paid vs. Total Shareholder Return

Compensation Actually Paid vs. Net Income

Compensation Actually Paid vs. Company Selected Measure

Total Shareholder Return Vs Peer Group

Tabular List, Table

Tabular List of Financial Performance Measures

For 2024, the most important financial measures used to link compensation actually paid to our performance are as follows: (i) total revenue; (ii) net loss; and (iii) TSR.

Total Shareholder Return Amount

$ 78

96

44

17

Peer Group Total Shareholder Return Amount

105

101

103

92

Net Income (Loss)

$ (39,000,000)

$ (66,000,000)

$ (67,000,000)

$ (158,000,000)

Company Selected Measure Amount

334,000,000

124,000,000

52,000,000

10,000,000

Michael Raab

Michael Raab

Michael Raab

Michael Raab

Pay vs Performance Disclosure

total revenue

Pay vs Performance Disclosure

net loss

Pay vs Performance Disclosure

TSR

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

$ (4,856,545)

PEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

(8,335,121)

PEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

2,972,646

PEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

(1,245,555)

PEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

1,251,140

PEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

500,345

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

(1,265,377)

Non-PEO NEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

(2,264,081)

Non-PEO NEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

919,554

Non-PEO NEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

(282,833)

Non-PEO NEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

247,178

Non-PEO NEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year

Pay vs Performance Disclosure

Adjustment to Compensation, Amount

$ 114,805