X0306 4/A 2022-05-27 2022-06-01 0 0001906324 QuidelOrtho Corp QDEL 0001436707 Smith Christopher M 9975 SUMMERS RIDGE ROAD SAN DIEGO CA 92121 1 0 0 0 Common Stock 2022-05-27 4 A 0 34554 A 34554 D The Form 4 originally filed on June 1, 2022 is being amended to correct the vesting schedule with respect to 29,418 restricted stock awards held by the reporting person. Pursuant to the Business Combination Agreement, dated as of December 22, 2021 (the "Business Combination Agreement") by and among Quidel Corporation, Ortho Clinical Diagnostics Holdings plc ("Ortho"), QuidelOrtho Corporation ("QuidelOrtho"), Orca Holdco, Inc., Laguna Merger Sub, Inc., and Orca Holdco 2, Inc., each ordinary share of Ortho beneficially owned by the Reporting Person at the effective time of the transaction contemplated by the Business Combination Agreement was exchanged for (i) 0.1055 shares of common stock of QuidelOrtho and (ii) $7.14 in cash. Includes 29,418 restricted stock awards, of which 4,203 shares vested on July 28, 2022, 16,811 shares will vest on September 9, 2022, 4,201 shares will vest on February 28, 2023 and 4,203 shares will vest on May 27, 2023. /s/ Phillip S. Askim, attorney-in-fact for Christopher M. Smith 2022-08-01