X0306 4 2014-08-04 0 0001436304 KYTHERA BIOPHARMACEUTICALS INC KYTH 0001416180 Leonard Keith R 30930 RUSSELL RANCH ROAD 3RD FLOOR WESTLAKE VILLAGE CA 91362 1 1 0 0 President & CEO Common Stock 2014-08-04 4 S 0 1828 35.0995 D 901274 I See footnote Common Stock 49649 I See footnote Common Stock 49649 I See footnote Common Stock 189 I See footnote Common Stock 189 I See footnote The sale reported on this Form 4 was effected pursuant to a Rule 10b5-1 trading plan which expires April 30, 2015. Shares held by Leonard Family Trust, dated August 28, 1996, Keith Richard Leonard, Jr. and Nanette LaRosa Leonard, Trustees. Shares held by Keith Richard Leonard, Jr., Retained Annuity Trust, Dated 12 April, 2010, Keith Richard Leonard, Jr., Trustee. Shares held by Nanette LaRosa Leonard, Retained Annuity Trust, Dated 12 April, 2010, Keith Richard Leonard, Jr., Trustee. Shares held by Keith R. Leonard III. Keith R. Leonard III is the son of the Reporting Person. Shares held by Nina R. Leonard. Nina R. Leonard is the daughter of the Reporting Person. The price reported in Column 4 is a weighted average sale price. The shares were sold in multiple transactions at prices ranging from $35.00 to $35.23, inclusive. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. Keith Klein, as Attorney-in-Fact for Keith R. Leonard 2014-08-05