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Stockholders' Equity (Details 3) (USD $)	3 Months Ended		6 Months Ended
Stockholders' Equity (Details 3) (USD $)	Jun. 30, 2013	Jun. 30, 2012	Jun. 30, 2013	Jun. 30, 2012
Stock-based compensation expense
Total compensation cost	$ 1,796,000	$ 453,000	$ 2,732,000	$ 809,000
Stock options
Stock-based compensation expense
Unrecognized compensation expense	11,933,000		11,933,000
Expected weighted-average period of recognition			2 years 6 months 4 days
Research and development
Stock-based compensation expense
Total compensation cost	1,046,000	210,000	1,476,000	366,000
General and administrative
Stock-based compensation expense
Total compensation cost	$ 750,000	$ 243,000	$ 1,256,000	$ 443,000

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

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