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Collaboration Agreements - Additional Information (Details) - USD ($)
1 Months Ended 3 Months Ended 12 Months Ended 48 Months Ended
Apr. 30, 2015
Mar. 31, 2019
Mar. 31, 2018
Jun. 30, 2016
Dec. 31, 2017
Mar. 31, 2019
Novartis Agreement            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]            
Payments received under collaboration agreement $ 200,000,000     $ 35,000,000   $ 1,600,000
Novartis share of joint development costs   38.00%        
Period after first commercial sale of product on which Novartis' royalty obligation run on a country to country basis   12 years        
Transaction price allocated to combined performance obligation   $ 236,600,000        
Revenue recognized   2,500,000 $ 3,600,000      
Deferred revenue   $ 174,100,000       174,100,000
Novartis Agreement | United States            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]            
Collaborative arrangement profit share percentage   50.00%        
Novartis Agreement | European Countries and Japan            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]            
Collaborative arrangement profit share percentage   45.00%        
Novartis Agreement | United States, Specified European Countries and /or Japan            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]            
Collaborative Agreement, Obligations   With respect to the United States, specified European countries and/or Japan, the Company may elect for such region to either reduce by 50% or to eliminate in full the Company’s development and commercialization cost sharing obligation. If the Company elects to reduce its cost sharing percentage by 50% in any such region, then its profit share in such region will also be reduced by 50%. If the Company elects to eliminate its development cost sharing obligation, then such region will be removed from the profit share, and instead Novartis will owe the Company royalties on any net sales of product for such region, as described above.        
Reduction percentage of development cost share   50.00%        
Reduction percentage of profit share   50.00%        
Novartis Agreement | Novartis            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]            
Novartis share of joint development costs   62.00%        
Collaborative arrangement profit share percentage   50.00%        
Novartis Agreement | Maximum            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]            
Development milestones amount eligible to receive   $ 215,000,000        
Regulatory approval milestones amount eligible to receive   250,000,000        
Lilly Agreement            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]            
Payments received under collaboration agreement   12,000,000        
Revenue recognized   1,400,000        
Deferred revenue   $ 11,400,000       $ 11,400,000
Royalty payments receivable terms   Lilly is also obligated to pay the Company tiered royalty payments at percentages in the single to low-double digits based on annual net sales of the licensed products. Lilly must pay such royalties on a product-by-product and country-by-country basis until the latest to occur of (i) the expiration of the last-to-expire valid claim of certain patents, (ii) the expiration of the data exclusivity period in such country or (iii) a specified anniversary of the first commercial sale of such product in such country.        
Lilly Agreement | Maximum            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]            
Milestone amount eligible to receive for products or product candidates   $ 620,000,000        
Merck License Agreement            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]            
Payments received under collaboration agreement     3,000,000   $ 2,000,000  
Remaining performance obligations     $ 0   $ 0  
Merck License Agreement | Maximum | Product Candidate            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]            
Milestone amount eligible to receive for products or product candidates   307,000,000        
Merck License Agreement | Maximum | Product            
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]            
Milestone amount eligible to receive for products or product candidates   $ 135,000,000