Equity Incentive Plans - Schedule of Black-Scholes Option-Pricing Model (Details)	12 Months Ended
Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Expected dividend yield	0.00%
2015 ESPP
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Expected term (in years)	6 months	6 months
Minimum \| 2015 ESPP
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Volatility	73.83%	71.70%
Risk-free interest rate	0.38%	0.08%
Maximum \| 2015 ESPP
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Volatility	74.39%	72.22%
Risk-free interest rate	0.62%	0.33%
Employees \| Minimum
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Expected term (in years)	5 years 3 months 18 days	5 years 3 months 18 days	5 years 3 months 18 days
Volatility	72.30%	70.20%	70.20%
Risk-free interest rate	1.25%	1.46%	1.85%
Employees \| Maximum
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Expected term (in years)	6 years 1 month 6 days	6 years 1 month 6 days	6 years 1 month 6 days
Volatility	74.50%	82.30%	77.30%
Risk-free interest rate	2.07%	1.92%	2.00%
Non Employees \| Minimum
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Expected term (in years)	6 years	9 years 1 month 6 days	9 years 3 months 18 days
Volatility	72.80%	72.10%	78.00%
Risk-free interest rate	1.35%	2.06%	2.19%
Non Employees \| Maximum
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Expected term (in years)	9 years 7 months 6 days	9 years 10 months 24 days	9 years 8 months 12 days
Volatility	74.30%	83.80%	78.10%
Risk-free interest rate	2.48%	2.36%	2.39%

The estimated dividend rate (a percentage of the share price) to be paid (expected dividends) to holders of the underlying shares over the option's term.

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- Definition

The estimated measure of the percentage by which a share price is expected to fluctuate during a period. Volatility also may be defined as a probability-weighted measure of the dispersion of returns about the mean. The volatility of a share price is the standard deviation of the continuously compounded rates of return on the share over a specified period. That is the same as the standard deviation of the differences in the natural logarithms of the stock prices plus dividends, if any, over the period.

+ References

+ Details

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- Definition

The risk-free interest rate assumption that is used in valuing an option on its own shares.

+ References

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- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

No definition available.

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- Definition

Expected term of share-based compensation awards, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (f)(2)(i)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SAB Topic 14.D.2)
-URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809

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