X0407 4 2023-04-01 0 0001435049 CHINOOK THERAPEUTICS, INC. KDNY 0001866746 Krishnan Mahesh C/O CHINOOK THERAPEUTICS, INC. 400 FAIRVIEW AVE. NO., 9TH FLOOR SEATTLE WA 98109 1 0 0 0 1 Common Stock 2023-04-01 4 M 0 2199 A 2199 D Common Stock 2023-04-04 4 S 0 924 23.01 D 1275 D Restricted Stock Units 2023-04-01 4 M 0 2199 0.00 D 2025-04-04 Common Stock 2199 4401 D Restricted stock units ("RSUs") convert into common stock on a one-for-one basis. The transactions reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person dated February 10, 2023. Each RSU represents a contingent right to receive one share of Issuer's common stock. The RSUs vests as to one-third (1/3) of the total restricted stock units in equal annual installments beginning on April 1, 2023, until fully vested subject to the Reporting Person's provision of service to the Issuer on each vesting date. /s/ Kirk Schumacher, Attorney-in-Fact 2023-04-04