X0306 4 2023-01-31 0 0001435049 CHINOOK THERAPEUTICS, INC. KDNY 0001823925 Frohlich Tom C/O CHINOOK THERAPEUTICS, INC. 400 FAIRVIEW AVE. NO., 9TH FLOOR SEATTLE WA 98109 0 1 0 0 Chief Operating Officer Common Stock 2023-01-31 4 M 0 8333 A 152240 D Common Stock 2023-01-31 4 S 0 4566 24.6824 D 147674 D Restricted Stock Unirt 2023-01-31 4 M 0 8333 0.00 D Common Stock 8333 16667 D Stock Option (Right to Buy) 25.27 2023-01-31 4 A 0 84000 0.00 A 2033-01-30 Common Stock 84000 84000 D Restricted Stock Unit 2023-01-31 4 A 0 21000 0.00 A Common Stock 21000 21000 D Restricted stock units ("RSUs") convert into common stock on a one-for-one basis. Represents the number of shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of RSUs. These sales are mandated by the Issuer's election under its equity incentive plans to require the satisfaction of a tax withholding obligation to be funded by a "sell to cover" transaction and do not represent discretionary trades by the Reporting Person. Each RSU represents a contingent right to receive one (1) share of the Issuer's Common Stock upon settlement. The RSUs vests as to one-third (1/3) of the total restricted stock units in equal annual installments beginning on January 31, 2023, until fully vested, subject to the reporting person's provision of service to the Issuer on each vesting date. The stock option vests as to 25% of the total shares on January 31, 2024, and thereafter vests as to 1/48 of the total shares monthly until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date. The RSUs vests as to one-third (1/3) of the total restricted stock units in equal annual installments beginning on January 31, 2024, until fully vested, subject to the reporting person's provision of service to the Issuer on each vesting date. /s/ Kirk Schumacher, Attorney-in-Fact 2023-02-02