X0306 4 2021-02-10 0 0001435049 CHINOOK THERAPEUTICS, INC. KDNY 0001823187 King Andrew James C/O CHINOOK THERAPEUTICS, INC. 1600 FAIRVIEW AVE. E. SEATTLE WA 98102 0 1 0 0 Head of Renal Discovery Stock Option (right to buy) 15.14 2021-02-10 4 A 0 60000 0.00 A 2031-02-09 Common Stock 60000 60000 D Restricted Stock (RSU)(Common Stock) 2021-02-10 4 A 0 20406 0.00 A 2024-02-10 Common Stock 20406 20406 D The stock option vests as to 25% of the total shares on February 10, 2022, and thereafter vests as to 1/48 of the total shares monthly until fully vested, subject to the Reporting Person's provision of service to the Issuer on each vesting date. Each RSU represents a contingent right to receive one (1) share of the Issuer's Common Stock upon settlement. The RSUs vests as to one-third (1/3) of the total restricted stock units in equal annual installments beginning on February 10, 2022, until fully vested, subject to the reporting person's provision of service to the Issuer on each vesting date. /s/ Kirk Schumacher, Attorney-in-Fact 2021-02-12