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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2023
Mar. 31, 2022
Cash Flows from Operating Activities    
Net loss $ (60,177) $ (31,684)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization expense 872 866
Loss on disposal of property and equipment   234
Amortization of intangible assets 433 429
Non-cash operating lease expense 1,626 1,528
Stock-based compensation expense 7,910 4,269
Change in fair value of contingent consideration and contingent value rights liabilities 526 (1,038)
Accretion of discounts and amortization of premiums on marketable securities (1,384) 406
Equity method investment loss 1,861 775
Changes in operating assets and liabilities:    
Accounts receivable (1,353) 7,114
Prepaid expenses and other assets 218 (3,155)
Accounts payable 13 745
Accrued and other liabilities (33) (4,191)
Operating lease liabilities (1,180) (1,020)
Net cash used in operating activities (50,668) (24,722)
Cash Flows from Investing Activities    
Purchases of marketable securities (64,140) (79,033)
Proceeds from marketable securities 97,500 23,834
Purchases of property and equipment (927) (374)
Net cash provided by (used in) investing activities 32,433 (55,573)
Cash Flows from Financing Activities    
Proceeds from exercise of stock options and warrants 1,666 2,049
Proceeds from at-the-market-sales agreement, net of issuance costs 19,600  
Previously incurred issuance costs related to an underwritten public offering paid during period   (286)
Net cash provided by financing activities 21,266 1,763
Effect of exchange rate changes on cash, cash equivalents and restricted cash 26 308
Net decrease in cash, cash equivalents and restricted cash 3,057 (78,224)
Cash, cash equivalents and restricted cash at beginning of period 117,512 183,798
Cash, cash equivalents and restricted cash at end of period 120,569 105,574
Reconciliation of Cash, Cash Equivalents and Restricted Cash    
Cash and cash equivalents 118,495 103,500
Restricted cash 2,074 2,074
Total cash, cash equivalents and restricted cash 120,569 105,574
Supplemental Cash Flow Information    
Cash paid for amounts included in the measurement of lease liabilities 1,895 1,861
Supplemental Disclosure of Non-Cash Investing and Financing Activities    
Purchases of property and equipment included in accounts payable and in accrued and other current liabilities $ 283 157
Receivable from option exercises   $ 1,325