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Collaboration and License Agreements - Additional Information (Details) - USD ($)
1 Months Ended 3 Months Ended
Dec. 31, 2019
Mar. 31, 2023
Mar. 31, 2022
Dec. 31, 2022
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Payable related to license agreement   $ 0   $ 0
Receivable related to license agreement   0   $ 0
China License Agreement | SanReno        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Revenue recognized   1,800,000 $ 2,700,000  
Progress-dependent milestone payments and royalties received   0 0  
China License Agreement | SanReno | Maximum        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Progress-dependent milestone receivable   25,000,000.0    
AbbVie Agreement        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Common stock shares issued 2,000,000.0      
Proceeds from issuance of common stock $ 6,700,000      
Milestone payment   0 0  
AbbVie Agreement | Maximum        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Contingent development, regulatory and commercial milestone payments   135,000,000.0    
Merck | Maximum | Product Candidate        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Milestone amount eligible to receive for products or product candidates   287,000,000.0    
Merck | Maximum | Product        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Milestone amount eligible to receive for products or product candidates   135,000,000.0    
Lilly Agreement        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Revenue recognized   0 $ 0  
Lilly Agreement | Maximum        
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]        
Milestone amount eligible to receive for products or product candidates   $ 463,000,000.0