<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2017-05-05</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001365916</issuerCik>
        <issuerName>AMYRIS, INC.</issuerName>
        <issuerTradingSymbol>AMRS</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001512375</rptOwnerCik>
            <rptOwnerName>Maxwell (Mauritius) Pte Ltd</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CIM CORPORATE SERVICES LTD,</rptOwnerStreet1>
            <rptOwnerStreet2>LES CASCADES, EDITH CAVELL STREET</rptOwnerStreet2>
            <rptOwnerCity>PORT LOUIS</rptOwnerCity>
            <rptOwnerState>O4</rptOwnerState>
            <rptOwnerZipCode></rptOwnerZipCode>
            <rptOwnerStateDescription>MAURITIUS</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001434871</rptOwnerCik>
            <rptOwnerName>Cairnhill Investments (Mauritius) Pte Ltd</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CIM CORPORATE SERVICES LTD,</rptOwnerStreet1>
            <rptOwnerStreet2>LES CASCADES, EDITH CAVELL STREET</rptOwnerStreet2>
            <rptOwnerCity>PORT LOUIS</rptOwnerCity>
            <rptOwnerState>O4</rptOwnerState>
            <rptOwnerZipCode></rptOwnerZipCode>
            <rptOwnerStateDescription>MAURITIUS</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001379348</rptOwnerCik>
            <rptOwnerName>Fullerton Management Pte Ltd</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>60B ORCHARD ROAD, #06-18 TOWER 2</rptOwnerStreet1>
            <rptOwnerStreet2>THE ATRIUM@ORCHARD</rptOwnerStreet2>
            <rptOwnerCity>SINGAPORE</rptOwnerCity>
            <rptOwnerState>U0</rptOwnerState>
            <rptOwnerZipCode>238891</rptOwnerZipCode>
            <rptOwnerStateDescription>SINGAPORE</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001021944</rptOwnerCik>
            <rptOwnerName>Temasek Holdings (Private) Ltd</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>60B ORCHARD ROAD, #06-18 TOWER 2</rptOwnerStreet1>
            <rptOwnerStreet2>THE ATRIUM@ORCHARD</rptOwnerStreet2>
            <rptOwnerCity>SINGAPORE</rptOwnerCity>
            <rptOwnerState>U0</rptOwnerState>
            <rptOwnerZipCode>238891</rptOwnerZipCode>
            <rptOwnerStateDescription>SINGAPORE</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>6.50% Convertible Senior Notes due 2019 (the &quot;Notes&quot;)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>3.74</value>
                <footnoteId id="F1"/>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2017-05-05</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>J</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionTotalValue>
                    <value>10000000.00</value>
                    <footnoteId id="F1"/>
                </transactionTotalValue>
                <transactionPricePerShare>
                    <value>0.00</value>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F1"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityValue>
                    <value>10000000.00</value>
                </underlyingSecurityValue>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>0</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F2"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">On May 5, 2017, Maxwell (Mauritius) Pte Ltd (&quot;Maxwell&quot;), the holder of the Notes, entered into a letter agreement with Amyris, Inc. (&quot;Amyris&quot;) whereby Amyris agreed to pay in cash any portion of the Notes that remains outstanding on the maturity date, and Maxwell waived its right to convert the Notes into shares of Amyris common stock.  Under the terms of the Notes, based on the initial conversion rate, the Notes were convertible into 2,670,370 shares of Amyris common stock. The termination of convertibility of the Notes could be deemed a &quot;disposition&quot; of a derivative security and/or the underlying common stock for purposes of Section 16 under the Securities Exchange Act of 1934, and the rules thereunder, and is reported herein solely for that reason.</footnote>
        <footnote id="F2">Maxwell directly owns the Notes. Maxwell is wholly-owned by Cairnhill Investments (Mauritius) Pte Ltd., which in turn is wholly-owned by Fullerton Management Pte Ltd, which in turn is wholly-owned by Temasek Holdings (Private) Limited. Therefore, each of Temasek Holdings (Private) Limited, Fullerton Management Pte Ltd and Cairnhill Investments (Mauritius) Pte Ltd. may be deemed to beneficially own the shares of derivative securities directly owned by Maxwell.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>MAXWELL (MAURITIUS) PTE LTD By:  /s/ Rooksana Shahabally, in her capacity as Director of Maxwell (Mauritius) Pte Ltd</signatureName>
        <signatureDate>2017-05-09</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>CAIRNHILL INVESTMENTS (MAURITIUS) PTE LTD By:  /s/ Rooksana Shahabally, in her capacity as Director of Cairnhill Investments (Mauritius) Pte Ltd</signatureName>
        <signatureDate>2017-05-09</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>FULLERTON MANAGEMENT PTE LTD By:  /s/ Cheong Kok Tim, in his capacity as Director of Fullerton Management Pte Ltd</signatureName>
        <signatureDate>2017-05-09</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>TEMASEK HOLDINGS (PRIVATE) LIMITED By:  /s/ Christina Choo, in her capacity as Authorized Signatory of Temasek Holdings (Private) Limited</signatureName>
        <signatureDate>2017-05-09</signatureDate>
    </ownerSignature>
</ownershipDocument>
