
Year	Summary Compensation Table Total for First PEO		Summary Compensation Table Total for Second PEO		Compensation Actually Paid to First PEO		Compensation Actually Paid to Second PEO		Average Summary Compensation Table Total for Other NEOs		Average Compensation Actually Paid to Other NEOs		Value of Initial Fixed $100 Investment Based On Total Stockholder Return		Value of Initial Fixed $100 Investment Based On Total Peer Group Return		Net Loss (in thousands)		Total Revenue (in thousands)
(a)	(b)		(b)		(c)		(c)		(d)		(e)		(f)		(g)		(h)		(i)
2024	$	3,175,240	$	—	$	2,729,864	$	—	$	1,379,914	$	977,475	$	8.46	$	90.58	$	(51,745)	$	332,314
2023	$	2,968,565	$	—	$	395,236	$	—	$	1,251,223	$	596,326	$	11.50	$	91.84	$	(209,248)	$	116,334
2022	$	3,799,412	$	—	$	4,773,987	$	—	$	1,412,466	$	1,797,309	$	23.96	$	88.53	$	(233,659)	$	75,475
2021	$	7,776,226	$	8,227,286	$	2,053,198	$	1,599,226	$	3,294,885	$	856,321	$	19.23	$	99.37	$	(269,108)	$	78,447

For 2024, 2023 and 2022, Mr. Koenig served as our PEO. For 2024, Dr. Foody, Mr. Halladay, Mr. Looker, and Mr. Warren served as our Other NEOs. For 2023, Dr. Foody and Mr. Warren served as our Other NEOs. For 2022, Dr. Foody and Mr. Looker served as our Other NEOs. For 2021, Mr. Koenig and Mr. Timothy Mayleben served as our PEO (First and Second in the table, respectively) and Mr. Bartram (Former Chief Financial Officer), Dr. Foody, and Ms. Ashley Hall (Former Chief Development Officer) served as our Other NEOs.

Adjustment To PEO Compensation, Footnote

The 2024 Summary Compensation Table totals for each PEO for each fiscal year were subject to the following adjustments per Item 402(v)(2)(iii) of Regulation S-K to calculate “compensation actually paid”:


Year	Summary Compensation Table Total for PEO 1		Equity Award Adjustments for PEO 1 (1)		Compensation Actually Paid to PEO 1		Summary Compensation Table Total for PEO 2		Equity Award Adjustments for PEO 2 (1)		Incremental Cost Adjustment for PEO 2 (2)		Compensation Actually Paid to PEO 2
2024	$	3,175,240	$	(445,376)	$	2,729,864	$	—	$	—	$	—	$	—
2023	$	2,968,565	$	(2,573,329)	$	395,236	$	—	$	—	$	—	$	—
2022	$	3,799,412	$	974,575	$	4,773,987	$	—	$	—	$	—	$	—
2021	$	7,776,226	$	(5,723,028)	$	2,053,198	$	8,227,286	$	(2,908,444)	$	(3,719,616)	$	1,599,226

(1) Equity award adjustment amounts reflect the aggregate of the following components, as applicable: (i) the fair value as of the end of the listed fiscal year of unvested equity awards granted in that fiscal year; (ii) the change in fair value during the listed fiscal year of equity awards granted in prior fiscal years that remained outstanding and unvested at the end of the listed fiscal year; and (iii) the change in fair value during the listed fiscal year through the vesting date of equity awards granted in prior fiscal years that vested during the listed fiscal year, less the fair value at the end of the prior fiscal year of awards granted prior to the listed fiscal year that failed to meet applicable vesting conditions during the listed fiscal year. Equity values are calculated in accordance with FASB ASC Topic 718, and the valuation assumptions used to calculate the fair values did not materially differ from those disclosed at the time of the grant. The amounts deducted or added in calculating the equity award adjustments are as follows:


Year	Change from Year End Fair Value of Outstanding and Unvested Equity Awards Granted in the Year		Year over Year Change in Fair Value of Outstanding and Unvested Equity Awards Granted in Prior Years		Change in Fair Value as of Vesting Date of Equity Awards Granted and Vested in the Year		Year over Year Change in Fair Value of Equity Awards Granted in Prior Years that Vested in the Year		Fair Value at the End of the Prior Year of Equity Awards that Failed to Meet Vesting Conditions in the Year		Value of Dividends or other Earnings Paid on Stock or Option Awards not Otherwise Reflected in Fair Value or Total Compensation		Total Equity Award Adjustments
PEO 1
2024	$	110,338	$	(328,101)	$	56,545	$	(284,158)	$	—	$	—	$	(445,376)
2023	$	(313,336)	$	(1,348,054)	$	(188,668)	$	(723,271)	$	—	$	—	$	(2,573,329)
2022	$	524,050	$	243,602	$	141,519	$	65,404	$	—	$	—	$	974,575
2021	$	(4,782,040)	$	—	$	(940,988)	$	—	$	—	$	—	$	(5,723,028)
PEO 2
2022	$	—	$	—	$	—	$	—	$	—	$	—	$	—
2021	$	(3,707,482)	$	—	$	28,166	$	3,379,913	$	(2,609,041)	$	—	$	(2,908,444)

(2) Represents incremental fair value from the modification of Mr. Mayleben's equity awards in accordance with FASB ASC Topic 718 associated with the terms of his separation agreement.

Non-PEO NEO Average Compensation Actually Paid Amount

$ 977,475

596,326

1,797,309

856,321

Compensation Actually Paid vs. Total Shareholder Return

Compensation Actually Paid vs. Company Selected Measure

Tabular List, Table


Additional Performance Measures
Total Revenue
Commercial growth (increased product sales)
Financial diligence (managing research and development, selling, general and administrative expenses and maintaining cash position)

Peer Group Total Shareholder Return Amount

90.58

91.84

88.53

99.37

Company Selected Measure Amount

332,314

116,334

75,475

78,447

Additional 402(v) Disclosure

The dollar amounts reported are the amounts of total compensation reported for Mr. Koenig and Mr. Mayleben for each corresponding year in the “Total” column of the "Summary Compensation Table." The dollar amounts reported are the average of the amounts of total compensation reported for our Other NEOs named in (a) for each corresponding year in the “Total” column of the "Summary Compensation Table".Cumulative TSR is calculated by dividing the sum of the cumulative amount of dividends for the measurement period, assuming dividend reinvestment, and the difference between the Company’s share price at the end and the beginning of the measurement period by the Company’s share price at the beginning of the measurement period. No dividends were paid on stock or option awards in 2021, 2022, 2023 or 2024.The dollar amounts reported represent the amount of net income (loss) reflected in the audited financial statements for the applicable year.The dollar amounts reported represent the amount of total revenue reflected in the audited financial statements for the applicable year.