Statements of Stockholders' Equity (Deficit) - USD ($) $ in Thousands	Total	Adoption of new accounting pronouncement	Common Stock	Additional Paid-In Capital	Additional Paid-In Capital Adoption of new accounting pronouncement	Accumulated Deficit	Accumulated Deficit Adoption of new accounting pronouncement	Treasury Stock	Accumulated Other Comprehensive Loss
Beginning balance (in shares) at Dec. 31, 2020			25,916,168
Beginning balance at Dec. 31, 2020	$ (96,134)	$ (91,927)	$ 26	$ 797,655	$ (93,475)	$ (838,817)	$ 1,548	$ (54,998)	$ 0
Increase (Decrease) in Stockholders' Equity
Issuance of common stock and warrants from offering, net of issuance costs (in shares)			32,142,858
Issuance of common stock and warrants from offering, net of issuance costs	208,730		$ 32	208,698
Issuance of common stock, net of issuance costs (in shares)			897,364
Issuance of common stock and warrants from offering, net of issuance costs	9,703		$ 1	9,702
Exchange of $15 million of convertible note to equity, net of issuance costs (in shares)			1,094,848
Exchange of convertible notes to equity, net of issuance costs	11,660		$ 1	11,659
Exercise of stock options (in shares)			491,700
Exercise of stock options	3,762		$ 1	3,761
Vesting of restricted stock units (in shares)			203,344
Vesting of restricted stock units	0
Vesting of ESPP Shares (in shares)			133,214
Vesting of ESPP Shares	2,095			2,095
Stock-based compensation	24,306			24,306
Other comprehensive gain (loss)	(31)								(31)
Net loss	(269,108)					(269,108)
Ending balance (in shares) at Dec. 31, 2021			60,879,496
Ending balance at Dec. 31, 2021	(196,944)		$ 61	964,401		(1,106,377)		(31)	(54,998)
Increase (Decrease) in Stockholders' Equity
Issuance of common stock, net of issuance costs (in shares)			13,043,797
Issuance of common stock and warrants from offering, net of issuance costs	$ 90,848		$ 13	90,835
Exercise of stock options (in shares)	0
Vesting of restricted stock units (in shares)			440,697
Vesting of restricted stock units	$ 1		$ 1
Vesting of ESPP Shares (in shares)			206,208
Vesting of ESPP Shares	732			732
Stock-based compensation	15,215			15,215
Other comprehensive gain (loss)	29								29
Net loss	(233,659)					(233,659)
Ending balance (in shares) at Dec. 31, 2022			74,570,198
Ending balance at Dec. 31, 2022	$ (323,778)		$ 75	$ 1,071,183		$ (1,340,036)		$ (2)	$ (54,998)