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Collaborations with Third Parties (Details) - USD ($)
1 Months Ended 3 Months Ended 6 Months Ended 12 Months Ended
Apr. 26, 2021
Apr. 17, 2020
Jan. 02, 2019
Apr. 30, 2021
Jun. 30, 2022
Jun. 30, 2021
Jun. 30, 2022
Jun. 30, 2021
Dec. 31, 2021
Collaborations with Third Parties                  
Collaboration revenue         $ 18,841,000 $ 40,659,000 $ 37,677,000 $ 48,637,000  
Collaboration revenue                  
Collaborations with Third Parties                  
Collaboration revenue         5,263,000 30,049,000 10,745,000 31,677,000  
Daiichi Sankyo Europe GmbH ("DSE") | Royalty revenue and product sales bulk tablets                  
Collaborations with Third Parties                  
Collaboration revenue         5,000,000 2,000,000 10,300,000 3,600,000  
Daiichi Sankyo Europe GmbH ("DSE") | License and Collaboration Agreement                  
Collaborations with Third Parties                  
Upfront cash payment received (paid)     $ 150,000,000            
Cash payment to the Company upon first commercial sales in the DSE Territory     $ 150,000,000            
Daiichi Sankyo Europe GmbH ("DSE") | License and Collaboration Agreement | Minimum                  
Collaborations with Third Parties                  
Percentage of royalties to be received on the net sales     15.00%            
Daiichi Sankyo Europe GmbH ("DSE") | License and Collaboration Agreement | Maximum                  
Collaborations with Third Parties                  
Percentage of royalties to be received on the net sales     25.00%            
Otsuka Pharmaceutical Co, Ltd. | Exclusive Developmental Activities                  
Collaborations with Third Parties                  
Upfront cash payment received (paid)   $ 60,000,000              
Potential additional future payments   $ 450,000,000              
Otsuka Pharmaceutical Co, Ltd. | Exclusive Developmental Activities | Collaboration revenue                  
Collaborations with Third Parties                  
Collaboration revenue             0 0  
Otsuka Pharmaceutical Co, Ltd. | Exclusive Developmental Activities | Minimum                  
Collaborations with Third Parties                  
Percentage of royalties to be received on the net sales   15.00%              
Otsuka Pharmaceutical Co, Ltd. | Exclusive Developmental Activities | Maximum                  
Collaborations with Third Parties                  
Percentage of royalties to be received on the net sales   30.00%              
Milestone payment, first JNDA submissions   $ 20,000,000              
Milestone payment, first NHI Price Listing for NEXLETOL in the Otsuka Territory   70,000,000              
Milestone payment, achievement of the primary MACE in the CLEAR Outcomes study and CV risk reduction rate on the U.S. label   50,000,000              
Milestone payments related to total net sales achievements   $ 310,000,000              
Daiichi Sankyo Co. Ltd                  
Collaborations with Third Parties                  
Collaboration revenue                 $ 28,500,000
Daiichi Sankyo Co. Ltd | License and Collaboration Agreement                  
Collaborations with Third Parties                  
Collaboration revenue         $ 200,000 28,100,000 400,000 $ 28,100,000 28,500,000
Consideration cash payment $ 30,000,000     $ 30,000,000          
Cash payment to be received upon certain commercial milestones       $ 175,000,000          
Deferred up-front payment             $ 1,100,000    
Daiichi Sankyo Co. Ltd | License and Collaboration Agreement | Minimum                  
Collaborations with Third Parties                  
Percentage of royalties to be received on the net sales       5.00%          
Daiichi Sankyo Co. Ltd | License and Collaboration Agreement | Maximum                  
Collaborations with Third Parties                  
Percentage of royalties to be received on the net sales       20.00%          
Daiichi Sankyo Co. Ltd | Collaborative Arrangement, License To Intellectual Property                  
Collaborations with Third Parties                  
Collaboration revenue           28,000,000     28,000,000
Daiichi Sankyo Co. Ltd | Collaborative Arrangement, Ongoing Regulatory And Development Activities                  
Collaborations with Third Parties                  
Collaboration revenue           $ 100,000     $ 500,000