Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Revenues:
Total Revenues	$ 78,447	$ 227,547	$ 148,364
Operating expenses:
Cost of goods sold	14,217	2,392	0
Research and development	105,975	146,936	175,611
Selling, general and administrative	184,985	199,615	65,854
Total operating expenses	305,177	348,943	241,465
Loss from operations	(226,730)	(121,396)	(93,101)
Interest expense	(46,353)	(22,670)	(8,120)
Other income, net	3,975	515	4,056
Net loss	$ (269,108)	$ (143,551)	$ (97,165)
Net loss per common share - basic (in dollars per share)	$ (9.31)	$ (5.23)	$ (3.59)
Net loss per common share - diluted (in dollars per share)	$ (9.31)	$ (5.23)	$ (3.59)
Weighted-average shares outstanding - basic (in shares)	28,902,507	27,473,873	27,090,284
Weighted-average shares outstanding - diluted (in shares)	28,902,507	27,473,873	27,090,284
Other comprehensive (loss) gain:
Unrealized (loss) gain on investments	$ (31)	$ (23)	$ 342
Total comprehensive loss	(269,139)	(143,574)	(96,823)
Product
Revenues:
Total Revenues	40,047	12,965	0
Collaboration Revenue
Revenues:
Total Revenues	$ 38,400	$ 214,582	$ 148,364