Income Taxes (Tables)

12 Months Ended

Dec. 31, 2021

Income Tax Disclosure [Abstract]

Schedule of Reconciliation of the U.S. Statutory Income Tax Rate to the Company's Effective Tax Rate

A reconciliation of the U.S. statutory income tax rate to the Company’s effective tax rate is as follows:

	December 31,
	2021		2020		2019
Federal income tax (benefit) at statutory rate	(21.0)	%	(21.0)	%	(21.0)	%
Change in state tax rate	0.9	%	—	%	(0.2)	%
Permanent items	0.1	%	0.6	%	(1.0)	%
R&D tax credits, net of reserves	—	%	(16.3)	%	—	%
Other	0.4	%	0.8	%	0.7	%
Change in valuation allowance	19.6	%	35.9	%	21.5	%
Effective income tax rate	0.0	%	0.0	%	0.0	%

Summary of Income Tax Contingencies

	December 31,
	2021		2020
	(in thousands)
Balance at January 1	$	2,606	$	—
Additions based on tax positions related to the current year	—		502
Additions for tax positions of prior years	—		2,104
Reductions for tax positions of prior year	(507)		—
Balance at December 31	2,099		2,606

Schedule of Significant Components of the Company's Deferred Tax Assets

Significant components of the Company’s deferred tax assets are summarized in the table below:

	December 31,
	2021		2020
	(in thousands)
Deferred tax assets:
Federal and state operating loss carryforwards	$	219,237	$	172,530
Equity compensation	22,735		21,454
R&D tax credits, net of reserves	18,887		23,452
Disallowed interest	16,146		5,307
Temporary differences	7,695		5,054
Total deferred tax assets	284,700		227,797
Deferred tax liabilities:
Convertible debt	—		(24,795)
Other	(546)		(159)
Total deferred tax liabilities	(546)		(24,954)
Valuation allowance	(284,154)		(202,843)
Net deferred tax assets	$	—	$	—