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Income Taxes - Reconciliation (Details)
12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Reconciliation of the U.S. statutory income tax rate to the Company's effective tax rate      
Federal income tax (benefit) at statutory rate (21.00%) (21.00%) (21.00%)
Change in state tax rate 0.00% (0.20%) 0.00%
Permanent items 0.60% (1.00%) (0.50%)
R&D tax credits, net of reserves (16.30%) 0.00% 0.00%
Other 0.80% 0.70% 0.50%
Change in valuation allowance 35.90% 21.50% 21.00%
Effective income tax rate 0.00% 0.00% 0.00%