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Property and Equipment (Detail) (USD $)
In Thousands, unless otherwise specified
12 Months Ended
Dec. 31, 2014
Dec. 31, 2013
Dec. 31, 2012
Property and Equipment      
Property and equipment, gross $ 1,183us-gaap_PropertyPlantAndEquipmentGross $ 769us-gaap_PropertyPlantAndEquipmentGross  
Less accumulated depreciation and amortization 403us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment 688us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment  
Property and equipment, net 780us-gaap_PropertyPlantAndEquipmentNet 81us-gaap_PropertyPlantAndEquipmentNet  
Depreciation expense 160us-gaap_Depreciation 71us-gaap_Depreciation 139us-gaap_Depreciation
Lab equipment      
Property and Equipment      
Property and equipment, gross 519us-gaap_PropertyPlantAndEquipmentGross
/ us-gaap_PropertyPlantAndEquipmentByTypeAxis
= espr_LabEquipmentMember
511us-gaap_PropertyPlantAndEquipmentGross
/ us-gaap_PropertyPlantAndEquipmentByTypeAxis
= espr_LabEquipmentMember
 
Computer equipment      
Property and Equipment      
Property and equipment, gross 110us-gaap_PropertyPlantAndEquipmentGross
/ us-gaap_PropertyPlantAndEquipmentByTypeAxis
= us-gaap_ComputerEquipmentMember
100us-gaap_PropertyPlantAndEquipmentGross
/ us-gaap_PropertyPlantAndEquipmentByTypeAxis
= us-gaap_ComputerEquipmentMember
 
Software      
Property and Equipment      
Property and equipment, gross 74us-gaap_PropertyPlantAndEquipmentGross
/ us-gaap_PropertyPlantAndEquipmentByTypeAxis
= us-gaap_SoftwareAndSoftwareDevelopmentCostsMember
119us-gaap_PropertyPlantAndEquipmentGross
/ us-gaap_PropertyPlantAndEquipmentByTypeAxis
= us-gaap_SoftwareAndSoftwareDevelopmentCostsMember
 
Furniture and fixtures      
Property and Equipment      
Property and equipment, gross 320us-gaap_PropertyPlantAndEquipmentGross
/ us-gaap_PropertyPlantAndEquipmentByTypeAxis
= us-gaap_FurnitureAndFixturesMember
11us-gaap_PropertyPlantAndEquipmentGross
/ us-gaap_PropertyPlantAndEquipmentByTypeAxis
= us-gaap_FurnitureAndFixturesMember
 
Leasehold improvements      
Property and Equipment      
Property and equipment, gross 158us-gaap_PropertyPlantAndEquipmentGross
/ us-gaap_PropertyPlantAndEquipmentByTypeAxis
= us-gaap_LeaseholdImprovementsMember
21us-gaap_PropertyPlantAndEquipmentGross
/ us-gaap_PropertyPlantAndEquipmentByTypeAxis
= us-gaap_LeaseholdImprovementsMember
 
Assets in Progress      
Property and Equipment      
Property and equipment, gross $ 2us-gaap_PropertyPlantAndEquipmentGross
/ us-gaap_PropertyPlantAndEquipmentByTypeAxis
= espr_AssetsInProgressMember
$ 7us-gaap_PropertyPlantAndEquipmentGross
/ us-gaap_PropertyPlantAndEquipmentByTypeAxis
= espr_AssetsInProgressMember