X0306 4 2023-01-09 0001434647 KEMPHARM, INC KMPH 0001698328 Sangiovanni Timothy J. C/O KEMPHARM, INC. 1180 CELEBRATION BOULEVARD, SUITE 103 CELEBRATION FL 34747 1 SVP, Corporate Controller Stock Option (right to buy) 4.54 2023-01-09 4 A 0 136986 0 A 2033-01-08 Common Stock 136986 136986 D Grant to the Reporting Person of a stock option under the Issuer's Amended and Restated 2014 Equity Incentive Plan (the "Plan"). 25% of the shares will vest on January 6, 2024 and the remaining 75% of the shares will vest in equal annual installments thereafter, provided that at the relevant vesting dates such optionee's employment relationship has not been terminated as defined in the Plan. All shares underlying the option will vest in full and become immediately exercisable upon a change of control of the Issuer or if the Reporting Person is terminated without cause or resigns for good reason. The option expires ten years after the date of grant. /s/ Timothy J. Sangiovanni 2023-01-11