Note I - Net Loss Per Share (Tables)

3 Months Ended

Mar. 31, 2019

Notes Tables

Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]

	Three months ended March 31,
	2019		2018
Warrants to purchase common stock		2,527,763		2,027,763
Awards under equity incentive plans		5,117,655		3,631,496
Deerfield Convertible Note		1,166,998		1,750,497
2021 Notes		4,481,182		5,040,914
Series A Convertible Preferred Stock		1,112,334		—
Total securities excluded from the calculation of weighted average number of shares of common stock outstanding		14,405,932		12,450,670