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Note H - Fair Value of Financial Instruments (Tables)
3 Months Ended
Mar. 31, 2019
Notes Tables  
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]
   
Balance as of
March 31,
2019
 
Quoted Prices
in
Active
Markets
for
Identical
Assets
(Level 1)
 
Significant
 
Other
Observable
Inputs
(Level 2)
 
Significant
Unobservable
Inputs
(Level 3)
Deerfield Warrant liability
  $
1,039
    $
    $
 —
    $
1,039
 
Embedded Warrant Put Option
   
288
     
     
 —
     
 288
 
Fundamental change and make-whole interest provisions embedded in 2021 Notes
   
     
     
 —
     
 —
 
Deerfield Note Conversion Feature    
94
     
     
     
94
 
KVK Warrant liability    
244
     
     
244
     
 
Total liabilities
  $
1,665
    $
   
 244
   
1,421
 
   
Balance as of
December
31,
2018
 
Quoted Prices
in
 Active
Markets for
Identical Assets
(Level 1)
 
Significant
Other
Observable
Inputs
(Level 2)
 
Significant
Unobservable
Inputs
(Level 3)
Deerfield Warrant liability
  $
1,557
    $
    $
    $
1,557
 
Embedded Warrant Put Option
   
154
     
     
     
154
 
Fundamental change and make-whole interest provisions embedded in 2021 Notes    
     
     
     
 
Deerfield Note Conversion Feature
   
134
     
     
     
134
 
KVK Warrant liability    
273
     
     
273
     
 
Total liabilities
  $
2,118
    $
    $
273
    $
1,845
 
Trading securities:
                               
Certificates of deposit
  $
246
    $
246
    $
    $
 
U.S. Treasury securities
   
3,014
     
3,014
     
     
 
Total assets
  $
3,260
    $
3,260
    $
    $
 
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]
   
Three months ended March 31,
   
2019
 
2018
Balance as of beginning of period
  $
1,845
    $
7,709
 
Adjustment to fair value
   
(424
)    
9,741
 
Balance as of end of period
  $
1,421
    $
17,450